:root{--bg-primary: #060a14;--bg-secondary: #0c1222;--bg-card: rgba(12, 18, 34, .9);--bg-glass: rgba(12, 18, 34, .75);--bg-hover: rgba(30, 41, 59, .6);--bg-sidebar: rgba(8, 12, 24, .95);--bg-input: rgba(15, 23, 42, .8);--text-primary: #f1f5f9;--text-secondary: #94a3b8;--text-muted: #64748b;--text-dim: #475569;--accent-cyan: #06d6a0;--accent-blue: #3b82f6;--accent-purple: #8b5cf6;--accent-pink: #ec4899;--accent-red: #ef4444;--accent-orange: #f59e0b;--accent-green: #22c55e;--gene-oncogene: #ef4444;--gene-suppressor: #3b82f6;--gene-neutral: #8b5cf6;--border: rgba(148, 163, 184, .1);--border-hover: rgba(148, 163, 184, .2);--border-glow: rgba(6, 214, 160, .25);--shadow-sm: 0 2px 8px rgba(0,0,0,.3);--shadow-md: 0 8px 24px rgba(0,0,0,.4);--shadow-lg: 0 20px 60px rgba(0,0,0,.5);--shadow-glow: 0 0 20px rgba(6, 214, 160, .1);--font-sans: "Inter", -apple-system, BlinkMacSystemFont, sans-serif;--font-mono: "JetBrains Mono", "Fira Code", monospace;--sidebar-width: 72px;--sidebar-expanded: 240px;--topbar-height: 56px;--radius-sm: 8px;--radius-md: 12px;--radius-lg: 16px;--radius-xl: 20px;--ease-out: cubic-bezier(.16, 1, .3, 1);--ease-spring: cubic-bezier(.34, 1.56, .64, 1)}*,*:before,*:after{margin:0;padding:0;box-sizing:border-box}html,body{width:100%;height:100%;overflow:hidden;background:var(--bg-primary);color:var(--text-primary);font-family:var(--font-sans);font-size:14px;line-height:1.5;-webkit-font-smoothing:antialiased}#app{display:flex;width:100%;height:100%}.sidebar{width:var(--sidebar-width);height:100%;background:var(--bg-sidebar);border-right:1px solid var(--border);display:flex;flex-direction:column;align-items:center;padding:12px 0;flex-shrink:0;z-index:100;transition:width .3s var(--ease-out);overflow:hidden}.sidebar:hover{width:var(--sidebar-expanded)}.sidebar-logo{width:42px;height:42px;background:linear-gradient(135deg,var(--accent-cyan),var(--accent-purple));border-radius:12px;display:flex;align-items:center;justify-content:center;font-size:20px;margin-bottom:24px;flex-shrink:0;animation:logoPulse 3s ease-in-out infinite;cursor:pointer}@keyframes logoPulse{0%,to{box-shadow:0 0 8px #06d6a04d}50%{box-shadow:0 0 20px #06d6a080}}.sidebar-nav{display:flex;flex-direction:column;gap:4px;width:100%;padding:0 10px;flex:1}.nav-item{display:flex;align-items:center;gap:14px;padding:10px 12px;border-radius:var(--radius-sm);color:var(--text-muted);cursor:pointer;transition:all .2s var(--ease-out);white-space:nowrap;overflow:hidden;text-decoration:none;font-size:13px;font-weight:500;border:1px solid transparent}.nav-item:hover{background:var(--bg-hover);color:var(--text-primary)}.nav-item.active{background:#06d6a01a;color:var(--accent-cyan);border-color:#06d6a033}.nav-icon{font-size:18px;width:28px;text-align:center;flex-shrink:0}.nav-label{opacity:0;transition:opacity .2s}.sidebar:hover .nav-label{opacity:1}.sidebar-footer{padding:12px;width:100%;border-top:1px solid var(--border);display:flex;align-items:center;justify-content:center}.sidebar-footer .status-dot{width:8px;height:8px;border-radius:50%;background:var(--accent-green);animation:blink 2s ease-in-out infinite}@keyframes blink{0%,to{opacity:1}50%{opacity:.3}}.main-content{flex:1;display:flex;flex-direction:column;overflow:hidden;min-width:0}.topbar{height:var(--topbar-height);padding:0 28px;display:flex;align-items:center;justify-content:space-between;border-bottom:1px solid var(--border);background:var(--bg-secondary);flex-shrink:0}.topbar-left{display:flex;align-items:center;gap:12px}.topbar-title{font-size:18px;font-weight:700;letter-spacing:-.02em}.topbar-subtitle{font-size:12px;color:var(--text-muted)}.topbar-right{display:flex;align-items:center;gap:16px}.topbar-stat{display:flex;align-items:center;gap:6px;font-size:12px;color:var(--text-secondary);padding:4px 12px;background:var(--bg-hover);border-radius:20px}.topbar-stat .val{font-family:var(--font-mono);font-weight:600;color:var(--accent-cyan)}.page-container{flex:1;overflow-y:auto;overflow-x:hidden;padding:28px;scroll-behavior:smooth}.card{background:var(--bg-card);border:1px solid var(--border);border-radius:var(--radius-lg);padding:24px;-webkit-backdrop-filter:blur(12px);backdrop-filter:blur(12px);transition:border-color .3s}.card:hover{border-color:var(--border-hover)}.card-header{display:flex;align-items:center;justify-content:space-between;margin-bottom:20px}.card-title{font-size:13px;font-weight:600;text-transform:uppercase;letter-spacing:.06em;color:var(--text-muted);display:flex;align-items:center;gap:8px}.card-title .icon{font-size:16px}.grid-2{display:grid;grid-template-columns:repeat(2,1fr);gap:20px}.grid-3{display:grid;grid-template-columns:repeat(3,1fr);gap:20px}.grid-4{display:grid;grid-template-columns:repeat(4,1fr);gap:20px}.grid-2-1{display:grid;grid-template-columns:2fr 1fr;gap:20px}.grid-1-2{display:grid;grid-template-columns:1fr 2fr;gap:20px}.grid-3-1{display:grid;grid-template-columns:3fr 1fr;gap:20px}.section{margin-bottom:28px}.section-title{font-size:20px;font-weight:700;margin-bottom:16px;letter-spacing:-.02em}.stat-card{padding:20px;border-radius:var(--radius-lg);border:1px solid var(--border);background:var(--bg-card);position:relative;overflow:hidden}.stat-card:before{content:"";position:absolute;top:0;left:0;width:100%;height:3px;background:var(--stat-color, var(--accent-cyan))}.stat-value{font-family:var(--font-mono);font-size:32px;font-weight:700;line-height:1;color:var(--stat-color, var(--accent-cyan))}.stat-label{font-size:12px;color:var(--text-muted);margin-top:6px;text-transform:uppercase;letter-spacing:.05em}.stat-change{font-size:11px;margin-top:8px;font-weight:500}.stat-change.up{color:var(--accent-green)}.stat-change.down{color:var(--accent-red)}.btn{display:inline-flex;align-items:center;gap:8px;padding:10px 20px;border-radius:var(--radius-md);font-family:var(--font-sans);font-size:13px;font-weight:600;cursor:pointer;border:1px solid transparent;transition:all .2s var(--ease-out)}.btn:active{transform:scale(.97)}.btn:disabled{opacity:.5;cursor:not-allowed}.btn-primary{background:linear-gradient(135deg,var(--accent-cyan),#059681);color:#fff;border:none}.btn-primary:hover{box-shadow:0 0 20px #06d6a04d;transform:translateY(-1px)}.btn-secondary{background:var(--bg-hover);color:var(--text-primary);border:1px solid var(--border)}.btn-secondary:hover{border-color:var(--accent-cyan);color:var(--accent-cyan)}.btn-danger{background:#ef444426;color:var(--accent-red);border:1px solid rgba(239,68,68,.3)}.btn-purple{background:linear-gradient(135deg,var(--accent-purple),#6d28d9);color:#fff;border:none}.btn-purple:hover{box-shadow:0 0 20px #8b5cf64d}.btn-lg{padding:14px 28px;font-size:15px;border-radius:var(--radius-lg)}.btn-sm{padding:6px 14px;font-size:11px}.btn-group{display:flex;gap:8px;flex-wrap:wrap}.gene-bar-list{display:flex;flex-direction:column;gap:8px}.gene-row{display:flex;align-items:center;gap:10px;padding:8px 12px;border-radius:var(--radius-sm);cursor:pointer;transition:background .2s}.gene-row:hover{background:var(--bg-hover)}.gene-name{font-family:var(--font-mono);font-size:12px;font-weight:600;width:56px;flex-shrink:0}.gene-name.oncogene{color:var(--gene-oncogene)}.gene-name.suppressor{color:var(--gene-suppressor)}.gene-name.neutral{color:var(--gene-neutral)}.gene-bar-track{flex:1;height:20px;background:#1e293b99;border-radius:6px;overflow:hidden}.gene-bar-fill{height:100%;border-radius:6px;transition:width .6s var(--ease-out);position:relative}.gene-bar-fill:after{content:"";position:absolute;right:0;top:0;bottom:0;width:15px;background:linear-gradient(90deg,transparent,rgba(255,255,255,.15))}.gene-value{font-family:var(--font-mono);font-size:12px;color:var(--text-secondary);width:44px;text-align:right}.gene-desc{font-size:11px;color:var(--text-dim);width:200px;white-space:nowrap;overflow:hidden;text-overflow:ellipsis}.gene-selector{display:flex;flex-wrap:wrap;gap:6px}.gene-chip{padding:8px 14px;border-radius:var(--radius-sm);background:var(--bg-input);border:1px solid var(--border);color:var(--text-secondary);font-family:var(--font-mono);font-size:12px;font-weight:500;cursor:pointer;transition:all .2s}.gene-chip:hover{border-color:var(--accent-cyan);color:var(--text-primary)}.gene-chip.selected{border-color:var(--accent-cyan);background:#06d6a01f;color:var(--accent-cyan);box-shadow:0 0 12px #06d6a026}.action-grid{display:grid;grid-template-columns:repeat(auto-fill,minmax(140px,1fr));gap:8px}.action-btn{padding:12px 16px;border-radius:var(--radius-md);background:var(--bg-input);border:1px solid var(--border);color:var(--text-secondary);font-family:var(--font-sans);font-size:12px;font-weight:500;cursor:pointer;transition:all .2s;display:flex;align-items:center;gap:8px}.action-btn:hover{border-color:var(--accent-blue);color:var(--text-primary)}.action-btn.selected{border-color:var(--accent-blue);background:#3b82f61f;color:var(--accent-blue)}.discovery-item{display:flex;align-items:center;gap:10px;padding:10px 14px;background:var(--bg-input);border-radius:var(--radius-sm);border-left:3px solid transparent;animation:slideIn .4s var(--ease-out);font-size:13px}.discovery-item.correct{border-left-color:var(--accent-green)}.discovery-item.incorrect{border-left-color:var(--accent-red)}@keyframes 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.mono{font-family:var(--font-mono);font-size:12px}.scene-container{position:relative;width:100%;border-radius:var(--radius-lg);overflow:hidden;border:1px solid var(--border)}.scene-canvas{display:block;width:100%}.scene-overlay{position:absolute;bottom:0;left:0;right:0;padding:16px 20px;background:linear-gradient(transparent,#060a14e6);display:flex;align-items:center;justify-content:space-between}.log-container{max-height:400px;overflow-y:auto;font-family:var(--font-mono);font-size:12px;padding:4px}.log-entry{padding:6px 10px;border-radius:4px;margin-bottom:2px;display:flex;align-items:center;gap:8px}.log-entry:nth-child(odd){background:#0f172a4d}.log-step{color:var(--text-dim);font-size:10px;width:36px;flex-shrink:0}.log-action{color:var(--accent-cyan)}.log-reward{color:var(--accent-orange);margin-left:auto}.hyp-card{padding:20px;border-radius:var(--radius-md);border:1px solid var(--border);background:var(--bg-card);transition:border-color 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var(--ease-out)}.loading-screen.hidden{opacity:0;pointer-events:none}.loading-helix{width:48px;height:48px;border:3px solid transparent;border-top-color:var(--accent-cyan);border-bottom-color:var(--accent-purple);border-radius:50%;animation:spin 1s linear infinite}@keyframes spin{to{transform:rotate(360deg)}}.loading-text{font-size:14px;color:var(--text-muted)}.empty-state{text-align:center;padding:48px 24px;color:var(--text-dim)}.empty-icon{font-size:36px;margin-bottom:12px}.empty-text{font-size:14px;margin-bottom:4px}.empty-sub{font-size:12px;color:var(--text-dim)}.heatmap-container{overflow-x:auto}.heatmap-cell{width:36px;height:36px;display:inline-flex;align-items:center;justify-content:center;font-family:var(--font-mono);font-size:9px;color:#ffffffb3;border-radius:4px;margin:1px}.paper-card{padding:16px 20px;border-radius:var(--radius-md);border:1px solid var(--border);background:var(--bg-card);transition:border-color .2s}.paper-card:hover{border-color:var(--border-hover)}.paper-title{font-size:14px;font-weight:500;color:var(--text-primary);line-height:1.5;margin-bottom:6px}.paper-meta{font-size:11px;color:var(--text-dim);display:flex;align-items:center;gap:12px}.paper-genes{font-family:var(--font-mono);font-size:11px;color:var(--accent-cyan);margin-top:6px}::-webkit-scrollbar{width:6px}::-webkit-scrollbar-track{background:transparent}::-webkit-scrollbar-thumb{background:var(--text-dim);border-radius:3px}::-webkit-scrollbar-thumb:hover{background:var(--text-muted)}@keyframes fadeIn{0%{opacity:0;transform:translateY(8px)}to{opacity:1;transform:translateY(0)}}.fade-in{animation:fadeIn .4s var(--ease-out)}.page-enter{animation:fadeIn .3s var(--ease-out)}.glass-panel{background:#0f172a80;backdrop-filter:blur(16px) saturate(180%);-webkit-backdrop-filter:blur(16px) saturate(180%);border:1px solid rgba(255,255,255,.08);box-shadow:0 8px 32px #0000004d}.glow-effect{position:relative;z-index:1}.glow-effect:before{content:"";position:absolute;top:-2px;left:-2px;right:-2px;bottom:-2px;background:linear-gradient(45deg,var(--accent-blue),var(--accent-purple),var(--accent-cyan));z-index:-1;border-radius:inherit;filter:blur(10px);opacity:0;transition:opacity .4s ease}.glow-effect:hover:before{opacity:.4}